Original publications

Original articles

Uusi artikkeli

Lehti S, Öörni K

Lorem ipsum blabla

Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo.

Judström I, Jukkola H, Metso J, Jauhiainen M, Kovanen PT, Lee-Rueckert M.

Atherosclerosis. 2010 Jan;208(1):148-54. Epub 2009 Jul 23.

OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface.

Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, Yan D, Olkkonen VM.

Exp Cell Res. 2010 Nov 15;316(19):3304-16. Epub 2010 Jun 16.

Cellular characteristics of non-allergic eosinophilic conjunctivitis.

Kari O, Haahtela T, Laine P, Turunen JP, Kari M, Sarna S, Laitinen T, Kovanen PT.

Acta Ophthalmol. 2010 Mar;88(2):245-50. Epub 2009 Nov 23.

Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart.

Toivonen R, Mäyränpää MI, Kovanen PT, Savontaus M.

Histochem Cell Biol. 2010 Mar;133(3):349-57. Epub 2009 Dec 2.

Partial filling affinity capillary electrophoresis with cationic poly(vinylpyrrolidone)-based copolymer coatings for studies on human lipoprotein-steroid interactions.

Wang AJ, Vainikka K, Witos J, D'Ulivo L, Cilpa G, Kovanen PT, Oörni K, Jauhiainen M, Riekkola ML.

Anal Biochem. 2010 Apr 1;399(1):93-101. Epub 2009 Nov 22.

Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation.

Heikkilä HM, Trosien J, Metso J, Jauhiainen M, Pentikäinen MO, Kovanen PT, Lindstedt KA.

J Cell Biochem. 2010 Feb 15;109(3):615-23.

FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.

Blom T, Bäck N, Mutka AL, Bittman R, Li Z, de Lera A, Kovanen PT, Diczfalusy U, Ikonen E.

Circ Res. 2010 Mar 5;106(4):720-9. Epub 2010 Jan 7.

An imbalance between CD36 and ABCA1 protein expression favors lipid accumulation in stroke-prone ulcerated carotid plaques.

Isoviita PM, Nuotio K, Saksi J, Turunen R, Ijäs P, Pitkäniemi J, Soinne L, Kaste M, Kovanen PT, Lindsberg PJ.

Stroke. 2010 Feb;41(2):389-93. Epub 2010 Jan 7.

The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice.

Shiota N, Kovanen PT, Eklund KK, Shibata N, Shimoura K, Niibayashi T, Shimbori C, Okunishi H.

Br J Pharmacol. 2010 Feb 1;159(3):626-35. Epub 2010 Jan 8.

Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase.

Plihtari R, Hurt-Camejo E, Oörni K, Kovanen PT.

J Lipid Res. 2010 Jul;51(7):1801-9. Epub 2010 Feb 1.

Membrane simulations mimicking acidic pH reveal increased thickness and negative curvature in a bilayer consisting of lysophosphatidylcholines and free fatty acids.

Lähdesmäki K, Ollila OH, Koivuniemi A, Kovanen PT, Hyvönen MT.

Biochim Biophys Acta. 2010 May;1798(5):938-46. Epub 2010 Feb 2.

Vascular endothelial growth factor-secreting mast cells and myofibroblasts: a novel self-perpetuating angiogenic pathway in aortic valve stenosis.

Syväranta S, Helske S, Laine M, Lappalainen J, Kupari M, Mäyränpää MI, Lindstedt KA, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1220-7. Epub 2010 Mar 18.

Open tubular capillary electrochromatography: a useful microreactor for collagen I glycation and interaction studies with low-density lipoprotein particles.

D'Ulivo L, Witos J, Oörni K, Kovanen PT, Riekkola ML.

Anal Chim Acta. 2010 Apr 7;664(2):185-9. Epub 2010 Feb 25.

Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vasoactive precursors in vitro.

Lehtinen R, Jauhiainen T, Kankuri E, Lindstedt K, Kovanen PT, Kerojoki O, Korpela R, Vapaatalo H.

Arzneimittelforschung. 2010;60(4):182-5.

Sugar treatment of human lipoprotein particles and their separation by capillary electrophoresis.

Witos J, Cilpa G, Yohannes G, Oörni K, Kovanen PT, Jauhiainen M, Riekkola ML.

J Sep Sci. 2010 Aug;33(16):2528-35.

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.

Rajamäki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, Kovanen PT, Eklund KK.

PLoS One. 2010 Jul 23;5(7):e11765.

Acidic extracellular environments strongly impair ABCA1-mediated cholesterol efflux from human macrophage foam cells.

Lee-Rueckert M, Lappalainen J, Leinonen H, Pihlajamaa T, Jauhiainen M, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1766-72. Epub 2010 Aug 11.

Transcardiac gradients of circulating apelin: extraction by normal hearts vs. release by hearts failing due to pressure overload.

Helske S, Kovanen PT, Lommi J, Turto H, Kupari M.

J Appl Physiol. 2010 Dec;109(6):1744-8. Epub 2010 Sep 23.

Lipoprotein(a) as a cardiovascular risk factor: current status.

Nordestgaard BG, Chapman MJ, Ray K, Borén J, Andreotti F, Watts GF, Ginsberg H, Amarenco P, Catapano A, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P, Masana L, Reiner Z, Taskinen MR, Tokgözoglu L, Tybjærg-Hansen A; European Atherosclerosis Society Consensus Panel.

Eur Heart J. 2010 Dec;31(23):2844-53. Epub 2010 Oct 21.

Mast cells generated from patients with atopic eczema have enhanced levels of granule mediators and an impaired Dectin-1 expression.

Ribbing C, Engblom C, Lappalainen J, Lindstedt K, Kovanen PT, Karlsson MA, Lundeberg L, Johansson C, Nilsson G, Lunderius-Andersson C, Scheynius A.

Allergy. 2011 Jan;66(1):110-9. doi: 10.1111/j.1398-9995.2010.02437.x.

Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apolipoprotein B conformation is involved in increased binding to proteoglycans.

Bancells C, Benítez S, Ordóñez-Llanos J, Öörni K, Kovanen PT, Milne RW, Sánchez-Quesada JL.

J Biol Chem. 2011 Jan 14;286(2):1125-33. Epub 2010 Nov 15.

OxLDL-IgG immune complexes induce expression and secretion of proatherogenic cytokines by cultured human mast cells.

Lappalainen J, Lindstedt KA, Oksjoki R, Kovanen PT.

Atherosclerosis. 2011 Feb;214(2):357-63. Epub 2010 Nov 26.

Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse.

Lee-Rueckert M, Silvennoinen R, Rotllan N, Judström I, Blanco-Vaca F, Metso J, Jauhiainen M, Kovanen PT, Escola-Gil JC.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):520-7. Epub 2011 Jan 6.

The effect of proatherogenic microbes on macrophage cholesterol homeostasis in apoE-deficient mice.

Tuomainen AM, Hyvärinen K, Ehlers PI, Mervaala E, Leinonen M, Saikku P, Kovanen PT, Jauhiainen M, Pussinen PJ.

Microb Pathog. 2011 Mar 21. [Epub ahead of print]

Do statins reduce the incidence of stroke in familial hypercholesterolemia?

Vuorio AF, Kovanen PT.

Expert Rev Cardiovasc Ther. 2011 Mar;9(3):349-53.

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway.

Niemi K, Teirilä L, Lappalainen J, Rajamäki K, Baumann MH, Oörni K, Wolff H, Kovanen PT, Matikainen S, Eklund KK.

J Immunol. 2011 Jun 1;186(11):6119-28. Epub 2011 Apr 20.

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management.

Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Borén J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P, Masana L, Nordestgaard BG, Ray KK, Reiner Z, Taskinen MR, Tokgözoglu L, Tybjærg-Hansen A, Watts GF; for the European Atherosclerosis Society Consensus Panel.

Eur Heart J. 2011 Jun;32(11):1345-1361. Epub 2011 Apr 29.

Acidity increases the uptake of native LDL by human monocyte-derived macrophages.

Plihtari R, Kovanen PT, Oörni K.

Atherosclerosis. 2011 Apr 22. [Epub ahead of print]

Three-Dimensional cryoEM Reconstruction of Native LDL Particles to 16Å Resolution at Physiological Body Temperature.

Kumar V, Butcher SJ, Oörni K, Engelhardt P, Heikkonen J, Kaski K, Ala-Korpela M, Kovanen PT.

PLoS One. 2011 May 9;6(5):e18841.

Gene expression differences between stroke-associated and asymptomatic carotid plaques.

Saksi J, Ijäs P, Nuotio K, Sonninen R, Soinne L, Salonen O, Saimanen E, Tuimala J, Lehtonen-Smeds EM, Kaste M, Kovanen PT, Lindsberg PJ.

J Mol Med. 2011 May 24. [Epub ahead of print]

 

Book chapters

Book chapters

Kovanen PT. The mast cell and its role in atherosclerosis and coronary artery disease. In: Mast Cells and Cardiovascular Disease. (Joseph J ed.) Nova Science Publisher, New York 2010; 111-136.

 

Kovanen PT. Mast cell proteases and atherosclerosis. In: Atherosclerosis: Cellular and molecular mechanisms. (George SJ, Johnson J eds.) Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 2010; 207-228.