Publications

Wihuri Research Institute Publications

Year 2017

Cedó L, Santos D, Ludwig IA, Silvennoinen R, García-León A, Kaipiainen L, Carbó JM, Valledor AF, Gylling H, Motilva MJ, Kovanen PT, Lee-Rueckert M, Blanco-Vaca F, Escolà-Gil JC. Phytosterol-mediated inhibition of intestinal cholesterol absorption in mice is independent of liver X receptor. Mol Nutr Food Res 2017 Mar 15. doi: 10.1002/mnfr.201700055.

Eklund L, Kangas J, Saharinen P. Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems. Clin Sci (Lond) 2017;131:87-103.

Ganjali S, Momtazi AA, Banach M, Kovanen PT, Stein EA, Sahebkar A. HDL abnormalities in familial hypercholesterolemia: Focus on biological functions. Prog Lipid Res 2017;67:16-26.

Hartman O, Kovanen PT, Lehtonen J, Eklund KK, Sinisalo J. Hydroxychloroquine for the prevention of recurrent cardiovascular events in myocardial infarction patients: rationale and design of the OXI trial. Eur Heart J Cardiovasc Pharmacother 2017;3:92-7.

Hartman O, Sinisalo J, Kovanen PT, Lehtonen J, Eklund KK. Congestive heart failure: more common as well as an important cardiovascular outcome: reply. Eur Heart J Cardiovasc Pharmacother 2017;3:99.

Heinolainen K, Karaman S, D’Amico G, Tammela T, Sormunen R, Eklund L, Alitalo K, Zarkada G.VEGFR3 modulates vascular permeability by controlling VEGF/VEGFR2 signaling. Circ Res 2017;120:1414-25.

Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. EMBO Mol Med 2017;9:750-69.

Jha SK, Rauniyar K, Karpanen T, Leppänen VM, Brouillard P, Vikkula M, Alitalo K, Jeltsch M. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. Sci Rep 2017;7:4916. doi: 10.1038/s41598-017-04982-1.

Karaman S, Alitalo K. ORAI1 controls the unique adjustment of lymphatics to fluid flow. Circ Res 2017;120:1373-5.

Karaman S, Alitalo K. Midkine and Melanoma Metastasis: A Malevolent Mix. Dev Cell 2017:7;42:205-7.

Kritikou E, Kuiper J, Kovanen PT, Bot I. The impact of mast cells on cardiovascular diseases.Eur J Pharmacol 2016;778:103-15.

Lampinen AM, Virman JP, Bono P, Luukkaala TH, Sunela KL, Kujala PM, Saharinen P, Kellokumpu-Lehtinen PI. Novel angiogenesis markers as long-term prognostic factors in patients with renal cell cancer. Clin Genitourin Cancer 2017;15:e15-e24.

Lee-Rueckert M, Escola-Gil JC, Kovanen PT. HDL functionality in reverse cholesterol transport – Challenges in translating data emerging from mouse models to human disease. Biochim Biophys Acta 2016;1861:566-83.

Leppänen VM, Saharinen P, Alitalo K. Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc Natl Acad Sci U S A 2017;114:4376-81.

Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M,4, Kipnis J. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. J Clin Invest 2017;127:3210-9.

Multia E, Sirén H, Andersson K, Samuelsson J, Forssén P, Fornstedt T, Öörni K, Jauhiainen M, Riekkola ML. Thermodynamic and kinetic approaches for evaluation of monoclonal antibody – Lipoprotein interactions. Anal Biochem 2017;518:25-34.

Naumenko N, Huusko J, Tuomainen T, Koivumäki JT, Merentie M, Gurzeler E, Alitalo K, Kivelä R, Ylä-Herttuala S, Tavi P. Vascular endothelial growth factor-B induces a distinct electrophysiological phenotype in mouse heart. Front Physiol 2017;8:373. doi: 10.3389/fphys.2017.00373. eCollection 2017.

Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. Retrograde lymph flow leads to chylothorax in transgenic mice with lymphatic malformations. Am J Pathol 2017;187:1984-97.

Nurmi K, Kareinen I, Virkanen J, Rajamäki K, Kouri VP, Vaali K, Levonen AL, Fyhrquist N, Matikainen S, Kovanen PT, Eklund KK. Hemin and cobalt protoporphyrin inhibit NLRP3 inflammasome activation by enhancing autophagy: A novel mechanism of inflammasome regulation. J Innate Immun 2017;9:65-82.

Saharinen P, Eklund L, Alitalo K. Therapeutic targeting of the angiopoietin-TIE pathway. Nat Rev Drug Discov 2017;16(9):635-61.

Sahebkar A, Simental-Mendía LE, Reiner Ž, Kovanen PT, Simental-Mendía M, Bianconi V, Pirro M. Effect of orlistat on plasma lipids and body weight: A systematic review and meta-analysis of 33   randomized controlled trials. Pharmacol Res 2017;122:53-65.

Sahebkar A, Simental-Mendía LE, Reiner Ž, Kovanen PT, Simental-Mendía M, Bianconi V, Pirro M. Statistical vs clinical significance: A matter of debate for orlistat treatment. Pharmacol Res 2017;124:158-9.

Shi GP, Bot I, Kovanen PT. Reply: The complexity of substance P-mediated mast cell activation. Nat Rev Cardiol 2017;14:124.

Silvennoinen R, Turunen JH, Kovanen PT, Syvänne M, Tikkanen MJ. Attitudes and actions: A survey to assess statin use among Finnish patients with increased risk for cardiovascular events. J Clin Lipidol 2017;11:485-94.

Vaahtomeri K, Karaman S, Mäkinen T, Alitalo K. Lymphangiogenesis guidance by paracrine and pericellular factors. Genes Dev 2017;31:1615-34.

Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, Sotlar K, Sperr WR, Escribano L, George TI, Kluin-Nelemans HC, Ustun C, Triggiani M, Brockow K, Gotlib J, Orfao A, Schwartz LB, Broesby-Olsen S, Bindslev-Jensen C, Kovanen PT, Galli SJ, Austen KF, Arber DA, Horny HP, Arock M, Metcalfe DD. Advances in the classification and treatment of mastocytosis: Current status and outlook toward the future. Cancer Res 2017;77:1261-70.

Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Tonstad S, Wiegman A, Drogari E, Ramaswami U. Statins for children with familial hypercholesterolemia. Cochrane Database Syst Rev 2017 Jul 7;7:CD006401. doi: 10.1002/14651858.CD006401

Vuorio A, Watts GF, Kovanen PT. Depicting new pharmacological strategies for familial hypercholesterolaemia involving lipoprotein (a). Eur Heart J 2017 Oct 3. doi: 10.1093/eurheartj/ehx546. [Epub ahead of print]

Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Del Monte-Nieto G, Zhuang Z, Charafeddine R, Kramer AH, Sibinga NE, Frangogiannis NG, Kitsis RN, Adams RH, Alitalo K, Sharp DJ, Harvey RP, Stanley P, Zhou B. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nat Commun 2017 Sep 18;8(1):578. doi: 10.1038/s41467-017-00654-w.

 

PhD Thesis

Satu Lehti, PhD: Extracellular lipid particles in atherosclerosis and aortic stenosis, University of Helsinki

 

Year 2016

Aspelund A, Robciuc MR, Karaman S, Mäkinen T, Alitalo K. Lymphatic system in cardiovascular medicine. Circ Res 2016;118:515-30.

Bui HM, Enis D, Robciuc MR, Nurmi HJ, Cohen J, Chen M, Yang Y, Dhillon V, Johnson K, Zhang H, Kirkpatrick R, Traxler E, Anisimov A, Alitalo K, Kahn ML. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. J Clin Invest 2016;126:2167-80.

Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, Lu P, Luo J, Wu Q, Alitalo K, Koh GY, Adams RH, He Y. Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII. Elife 2016 Dec 22;5. pii: e21032. doi: 10.7554/eLife.21032.

Dashkevich A, Raissadati A, Syrjälä SO, Zarkada G, Keränen MA, Tuuminen R, Krebs R, Anisimov A, Jeltsch M, Leppänen VM, Alitalo K, Nykänen AI, Lemström KB. Ischemia-reperfusion injury enhances lymphatic endothelial VEGFR3 and rejection in cardiac allografts. Am J Transplant 2016;16:1160-72.

Da Silva RF, Lappalainen J, Lee-Rueckert M, Kovanen PT. Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation. Atherosclerosis 2016;248:170-8.

Dichlberger A, Schlager S, Kovanen PT, Schneider WJ. Lipid droplets in activated mast cells – a significant source of triglyceride-derived arachidonic acid for eicosanoid production. Eur J Pharmacol 2016;785:59-69.

Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K.Critical requirement of VEGF-C in transition to fetal erythropoiesis. Blood 2016;128:710-20.

Gan N, Multia E, Sirén H, Ruuth M, Öörni K, Maier NM, Jauhiainen M, Kemell M, Riekkola ML.Tailor-made approach for selective isolation and elution of low-density lipoproteins by immunoaffinity sorbent on silica. Anal Biochem 2016;514:12-23.

Honkanen HK, Izzi V, Petäistö T, Holopainen T, Harjunen V, Pihlajaniemi T, Alitalo K, Heljasvaara R.Elevated VEGF-D Modulates tumor inflammation and reduces the growth of carcinogen-induced skin tumors. Neoplasia 2016;18:436-46.

Johns SC, Yin X, Jeltsch M, Bishop JR, Schuksz M, El Ghazal R, Wilcox-Adelman SA, Alitalo K, Fuster MM. Functional importance of a proteoglycan coreceptor in pathologic lymphangiogenesis. Circ Res 2016;119:210-21.

Karaman S, Hollmén M, Yoon SY, Alkan HF, Alitalo K, Wolfrum C, Detmar M. Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice. Sci Rep 2016 Aug 11;6:31566. doi: 10.1038/srep31566.

Kim M, Allen B, Korhonen EA, Nitschké M, Yang HW, Baluk P, Saharinen P, Alitalo K, Daly C, Thurston G, McDonald DM. Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest 2016;126:3511-25.

Kivelä R, Salmela I, Nguyen YH, Petrova TV, Koistinen HA, Wiener Z, Alitalo K. The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation. Nat Commun 2016 Oct 12;7:13124. doi: 10.1038/ncomms13124.

Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D’Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, Alitalo K, Saharinen P. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest 2016;126:3495-510.

Kritikou E, Kuiper J, Kovanen PT, Bot I. The impact of mast cells on cardiovascular diseases. Eur J Pharmacol 2016;778:103-15.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M. USF1 deficiency activates brown adipose tissue and improves cardiometabolic health. Sci Transl Med 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.

Lee-Rueckert M, Escola-Gil JC, Kovanen PT. HDL functionality in reverse cholesterol transport – Challenges in translating data emerging from mouse models to human disease. Biochim Biophys Acta 2016;1861:566-83.

Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest 2016;126:3389-402.

Nguyen SD, Maaninka K, Lappalainen J, Nurmi K, Metso J, Öörni K, Navab M, Fogelman AM, Jauhiainen M, Lee-Rueckert M, Kovanen PT. Carboxyl-terminal cleavage of apolipoprotein A-I by human mast cell chymase impairs its anti-inflammatory properties. Arterioscler Thromb Vasc Biol   2016;36:274-84.

Nissinen TA, Degerman J, Räsänen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, Kivelä R, Hulmi JJ. Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep 2016 Sep 26;6:32695. doi: 10.1038/srep32695.

Ollikainen E, Tulamo R, Lehti S, Lee-Rueckert M, Hernesniemi J, Niemelä M, Ylä-Herttuala S, Kovanen PT, Frösen J. Smooth muscle cell foam cell formation, apolipoproteins, and ABCA1 in intracranial aneurysms: Implications for lipid accumulation as a promoter of aneurysm wall rupture. J Neuropathol Exp Neurol 2016;75:689-99.

Palomäki A, Hällberg V, Ala-Korpela M, Kovanen PT, Malminiemi K. Prompt impact of first prospective statin mega-trials on postoperative lipid management of CABG patients: a 20-year follow-up in a single hospital. Lipids Health Dis 2016;15:124. doi: 10.1186/s12944-016-0292-6.

Raissadati A, Tuuminen R, Dashkevich A, Bry M, Kivelä R, Anisimov A, Syrjälä S, Arnaudova R, Rouvinen E, Keränen MA, Krebs R, Nykänen AI, Lemström KB. Vascular endothelial growth factor-B overexpressing hearts are not protected from transplant-associated ischemia-reperfusion injury. Exp Clin Transplant 2016 Sep 1. doi: 10.6002/ect.2016.0181. [Epub ahead of print].

Rajamäki K, Mäyränpää MI, Risco A, Tuimala J, Nurmi K, Cuenda A, Eklund KK, Öörni K, Kovanen PT. p38δ MAPK: A novel regulator of NLRP3 inflammasome activation with increased expression in coronary atherogenesis. Arterioscler Thromb Vasc Biol 2016;36:1937-46.

Rautiola J, Lampinen A, Mirtti T, Ristimäki A, Joensuu H, Bono P, Saharinen P. Association of Angiopoietin-2 and Ki-67 expression with vascular density and sunitinib response in metastatic renal cell carcinoma. PLoS One. 2016;11:e0153745. doi: 10.1371.

Robciuc MR, Kivelä R, Williams IM, de Boer JF, van Dijk TH, Elamaa H, Tigistu-Sahle F, Molotkov D, Leppänen VM, Käkelä R, Eklund L, Wasserman DH, Groen AK, Alitalo K. VEGFB/VEGFR1-induced expansion of adipose vasculature counteracts obesity and related metabolic complications. Cell Metab 2016;23:712-24.

Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K. VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A 2016;113:13144-9.

Schaupper MV, Jeltsch M, Rohringer S, Redl H, Holnthoner W. Lymphatic vessels in regenerative medicine and tissue engineering. Tissue Eng Part B Rev 2016;22:395-407.

Sinisalo J, Vlachopoulou E, Marchesani M, Nokelainen J, Mäyränpää MI, Lappalainen J, Paakkanen R, Wennerström A, Salli K, Niemi HJ, Männistö S, Salo P, Junttila J, Eskola M, Nikus K, Arstila TP, Perola M, Huikuri H, Karhunen PJ, Kovanen PT, Palotie A, Havulinna AS, Lluis-Ganella C, Marrugat J, Elosua R, Salomaa V, Nieminen MS, Lokki ML. Novel 6p21.3 risk haplotype predisposes to acute coronary syndrome. Circ Cardiovasc Genet 2016;9:55-63.

Vuorio A, Strandberg TE, Schneider WJ, Kovanen PT. Statins and new-onset diabetes mellitus – a risk lacking in familial hypercholesterolaemia. J Intern Med 2016;279:358-61.

Vuorio A, Strandberg TE, Schneider WJ, Kovanen PT. Response to Dr. Gerald M Reaven: good news for patients with familial hypercholesterolaemia: statins are not diabetogenic in this disease. J Intern Med 2016;280:419-20.

Vuorio A, Watts GF, Kovanen PT. Initiation of PCSK9 inhibition in patients with heterozygous familial hypercholesterolaemia entering adulthood: a new design for living with a high-risk condition? Eur Heart J 2016;37:1353-6.

Vuorio A, Watts GF, Kovanen PT. Rescue therapy with PCSK9 inhibitors for patients with delayed diagnosis of heterozygous familial hypercholesterolemia: Redressing the balance of missed opportunities. J Clin Lipidol 2016;10:1278-9.

 

Year 2015

Annema W, von Eckardstein A, Kovanen PT. HDL and atherothrombotic vascular disease. Handb Exp Pharmacol 2015;224:369-403.

Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 2015;212:991-9.

Bot I, Shi GP, Kovanen PT. Mast cells as effectors in atherosclerosis. Arterioscler Thromb Vasc Biol 2015;35:265-71.

Choe K, Jang JY, Park I, Kim Y, Ahn S, Park DY, Hong YK, Alitalo K, Koh GY, Kim P. Intravital imaging of intestinal lacteals unveils lipid drainage through contractility. J Clin Invest 2015;125:4042-52.

Escolà-Gil JC, Lee-Rueckert M, Santos D, Cedó L, Blanco-Vaca F, Julve J. Quantification of in vitro macrophage cholesterol efflux and in vivo macrophage-specific reverse cholesterol transport. Methods Mol Biol 2015;1339:211-33.

Estruch M, Rajamäki K, Sanchez-Quesada JL, Kovanen PT, Öörni K, Benitez S, Ordoñez-Llanos J.Electronegative LDL induces priming and inflammasome activation leading to IL-1β release in human monocytes and macrophages. Biochim Biophys Acta. 2015;1851:1442-9.

Hakanpää L, Sipilä T, Leppänen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P. Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nat Commun 2015;6:5962. doi: 10.1038/ncomms6962.

Han J, Calvo CF, Kang TH, Baker KL, Park JH, Parras C, Levittas M, Birba U, Pibouin-Fragner L, Fragner P, Bilguvar K, Duman RS, Nurmi H, Alitalo K, Eichmann AC, Thomas JL. Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans. Cell Rep 2015;10:1158-72.

Helske-Suihko S, Laine M, Lommi J, Kaartinen M, Werkkala K, Kovanen PT, Kupari M. Is blockade of the Renin-Angiotensin system able to reverse the structural and functional remodeling of the left ventricle in severe aortic stenosis? J Cardiovasc Pharmacol 2015;65:233-40.

Holopainen T, Räsänen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivelä R, Alitalo K. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proc Natl Acad Sci U S A 2015;112:13063-8.

Kareinen I, Cedó L, Silvennoinen R, Laurila PP, Jauhiainen M, Julve J, Blanco-Vaca F, Escola-Gil JC, Kovanen PT, Lee-Rueckert M. Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice. J Lipid Res 2015;56:241-53.

Kovanen PT, Jauhiainen M. Coronary heart disease prediction: Apolipoprotein B shows its might again – but still in vain? Eur J Prev Cardiol 2015;22:1317-20.

Lee-Rueckert M, Kovanen PT. The mast cell as a pluripotent HDL-modifying effector in atherogenesis: from in vitro to in vivo significance. Curr Opin Lipidol 2015;26:362-8.

Lehti S, Sjövall P, Käkelä R, Mäyränpää MI, Kovanen PT, Öörni K. Spatial distributions of lipids in atherosclerosis of human coronary arteries studied by time-of-flight secondary ion mass spectrometry. Am J Pathol 2015;185:1216-33.

Magné J, Gustafsson P, Jin H, Maegdefessel L, Hultenby K, Wernerson A, Eriksson P, Franco-Cereceda A, Kovanen PT, Gonçalves I, Ehrenborg E. ATG16L1 expression in carotid atherosclerotic plaques Is associated with plaque vulnerability. Arterioscler Thromb Vasc Biol 2015;35:1226-35.

Martinez-Corral I, Ulvmar MH, Stanczuk L, Tatin F, Kizhatil K, John SW, Alitalo K, Ortega S, Mäkinen T. Nonvenous origin of dermal lymphatic vasculature. Circ Res 2015;116:1649-54.

Nguyen SD, Javanainen M, Rissanen S, Zhao H, Huusko J, Kivelä AM, Ylä-Herttuala S, Navab M, Fogelman AM, Vattulainen I, Kovanen PT, Öörni K. Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation. J Lipid Res 2015;56:1206-21.

Nuotio K, Soinne L, Hänninen H, Saksi J, Tuimala J, Jula A, Kovanen PT, Kaste M, Ijäs P, Lindsberg PJ. Life-threatening coronary disease is prevalent in patients with stenosing carotid artery disease. Int J Stroke 2015;10:1217–1223.

Nurmi H, Saharinen P, Zarkada G, Zheng W, Robciuc MR, Alitalo K. VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption. EMBO Mol Med 2015;7:1418-25.

Ohukainen P, Syväranta S, Näpänkangas J, Rajamäki K, Taskinen P, Peltonen T, Helske-Suihko S, Kovanen PT, Ruskoaho H, Rysä J. MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease. Ann Med 2015;47:423-9

Roukens MG, Peterson-Maduro J, Padberg Y, Jeltsch M, Leppänen VM, Bos FL, Alitalo K, Schulte-Merker S, Schulte D. Functional dissection of the CCBE1 protein: a crucial requirement for the collagen repeat domain. Circ Res 2015;116:1660-9.

Saharinen P, Ivaska J. Blocking integrin inactivation as an anti-angiogenic therapy. EMBO J 2015;34:1293-5.

Shi GP, Bot I, Kovanen PT. Mast cells in human and experimental cardiometabolic diseases. Nat Rev Cardiol 2015;12:643-58.

Silvennoinen R, Quesada H, Kareinen I, Julve J, Kaipiainen L, Gylling H, Blanco-Vaca F, Escola-Gil JC, Kovanen PT, Lee-Rueckert M. Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice. Physiol Rep 2015;3. pii: e12402. doi: 10.14814

Simonen P, Lommi J, Hallikainen M, Helske-Suihko S, Werkkala K, Kupari M, Kovanen PT, Gylling H. Dietary plant stanols or sterols neither accumulate in stenotic aortic valves nor influence their structure or inflammatory status. Clin Nutr 2015;34:1251-7.

Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Laviña B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T. cKit lineage hemogenic endothelium-derived cells contribute to mesenteric lymphatic vessels. Cell Rep 2015;10:1708-21.

Syrjälä SO, Nykänen AI, Tuuminen R, Raissadati A, Keränen MA, Arnaudova R, Krebs R, Koh GY, Alitalo K, Lemström KB. Donor heart treatment with COMP-Ang1 limits ischemia-reperfusion injury and rejection of cardiac allografts. Am J Transplant 2015;15:2075-84.

Tamminen K, Balboa D, Toivonen S, Pakarinen MP, Wiener Z, Alitalo K, Otonkoski T. Intestinal commitment and maturation of human pluripotent stem cells is independent of exogenous FGF4 and R-spondin1. PLoS One 2015;10:e0134551. doi: 10.1371.

Tervala TV, Hartiala P, Tammela T, Visuri MT, Ylä-Herttuala S, Alitalo K, Saarikko AM. Growth factor therapy and lymph node graft for lymphedema. J Surg Res 2015;196:200-7.

Theelen TL, Lappalainen JP, Sluimer JC, Gurzeler E, Cleutjens JP, Gijbels MJ, Biessen EA, Daemen MJ, Alitalo K, Ylä-Herttuala S. Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice. Atherosclerosis 2015;241:297-304.

Turkki R, Linder N, Holopainen T, Wang Y, Grote A, Lundin M, Alitalo K, Lundin J. Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis. J Clin Pathol 2015;68:614-21.

Visuri MT, Honkonen KM, Hartiala P, Tervala TV, Halonen PJ, Junkkari H, Knuutinen N, Ylä-Herttuala S, Alitalo KK, Saarikko AM. VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study. Angiogenesis 2015;18:313-26.

Vuorio A, Kaste M, Kovanen PT. Combination of intracerebral haemorrhage and familial hypercholesterolemia in the acute hospital setting–a challenge for statin treatment? Int J Stroke 2015;10:467-8.

Wang J, Sukhova GK, Liu J, Ozaki K, Lesner A, Libby P, Kovanen PT, Shi GP. Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice. 2015;62:1615-24.

Wiegman A, Gidding SS, Watts GF, Chapman MJ, Ginsberg HN, Cuchel M, Ose L, Averna M, Boileau C, Borén J, Bruckert E, Catapano AL, Defesche JC, Descamps OS, Hegele RA, Hovingh GK, Humphries SE, Kovanen PT, Kuivenhoven JA, Masana L, Nordestgaard BG, Pajukanta P, Parhofer KG, Raal FJ, Ray KK, Santos RD, Stalenhoef AF, Steinhagen-Thiessen E, Stroes ES, Taskinen MR, Tybjærg-Hansen A, Wiklund O; European Atherosclerosis Society Consensus Panel. Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. Eur Heart J 2015;36:2425-37.

Zarkada G, Heinolainen K, Mäkinen T, Kubota Y, Alitalo K. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci U S A 2015;112:761-6.

Öörni K, Rajamäki K, Nguyen SD, Lähdesmäki K, Plihtari R, Lee-Rueckert M, Kovanen PT. Acidification of the intimal fluid: the perfect storm for atherogenesis. J Lipid Res 2015;56:203-14.

PhD Thesis

Ilona Kareinen, DVT: Mast cells and HDL studies on cholesterol efflux and reverse cholesterol transport, University of Helsinki

Katariina Nurmi, PhD: Inhibition of inflammatory cellurar responses by ethanol and heme-novel mechanism of inflammatory responses and inflammation, University of Helsinki

Kristiina Rajamäki, PhD: Role of the inflammasome pathway in atherosclerosis, University of Helsinki

Reija Silvennoinen, PhD: Physiological modulation of the reverse cholesterol transport pathway in vivo, University of Helsinki

Year 2014

Alanne-Kinnunen M, Lappalainen J, Oörni K, Kovanen PT. Activated Human Mast Cells Induce LOX-1-Specific Scavenger Receptor Expression in Human Monocyte-Derived Macrophages. PLoS One 2014;9:e108352. doi: 10.1371

Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T, Saharinen P, Immonen I, Alitalo K. The Schlemm’s canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest 2014;124:3975-86.

Bry M, Kivelä R, Leppänen VM, Alitalo K. Vascular endothelial growth factor-B in physiology and disease. Physiol Rev 2014;94:779-794.

Chen HI, Poduri A, Nurmi H, Kivela R, Saharinen P, McKay AS, Raftrey B, Churko J, Tian X, Zhou B, Wu JC, Alitalo K, Red-Horse K. VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest 2014;124:4899-914

Chen HI, Sharma B, Akerberg BN, Nurmi HJ, Kivelä R, Saharinen P, Aghajanian H, McKay AS, Bogard PE, Chang AH, Jacobs AH, Epstein JA, Stankunas K, Alitalo K, Red-Horse K. The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis. Development 2014;141:4500-12.

Cuchel M, Bruckert E, Ginsberg HN, Raal FJ, Santos RD, Hegele RA, Kuivenhoven JA, Nordestgaard BG, Descamps OS, Steinhagen-Thiessen E, Tybjærg-Hansen A, Watts GF, Averna M, Boileau C, Borén J, Catapano AL, Defesche JC, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Ray KK, Stalenhoef AF, Stroes E, Taskinen MR, Wiegman A, Wiklund O, Chapman MJ; for the European Atherosclerosis Society Consensus Panel on Familial Hypercholesterolaemia. Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. Eur Heart J 2014;35:2146-57.

D’Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hägerling R, Kiefer F, Eklund L, Sormunen R, Elamaa H, Brekken RA, Adams RH, Koh GY, Saharinen P, Alitalo K. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest 2014;124:824-834.

Dichlberger A, Schlager S, Maaninka K, Schneider WJ, Kovanen PT. Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. J Lipid Res 2014;55:2471-8.

Dijkstra MH, Pirinen E, Huusko J, Kivelä R, Schenkwein D, Alitalo K, Ylä-Herttuala S. Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice. Sci Rep 2014;4:6238. doi:10.1038.

Gylling H, Plat J, Turley S, Ginsberg HN, Ellegård L, Jessup W, Jones PJ, Lütjohann D, Maerz W, Masana L, Silbernagel G, Staels B, Borén J, Catapano AL, De Backer G, Deanfield J, Descamps OS, Kovanen PT, Riccardi G, Tokgözoglu L, Chapman MJ; European Atherosclerosis Society Consensus Panel on Phytosterols. Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis 2014;232:346-360.

Hegele RA, Ginsberg HN, Chapman MJ, Nordestgaard BG, Kuivenhoven JA, Averna M, Borén J, Bruckert E, Catapano AL, Descamps OS, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Raal FJ, Ray KK, Santos RD, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A, Watts GF, Wiklund O; European Atherosclerosis Society Consensus Panel. The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol 2014;2:655-66.

Jeltsch M, Jha SK, Tvorogov D, Anisimov A, Leppänen VM, Holopainen T, Kivelä R, Ortega S, Kärpanen T, Alitalo K. CCBE1 enhances lymphangiogenesis via a disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Circulation 2014;129:1962-71.

Karaman S, Hollmén M, Robciuc MR, Alitalo A, Nurmi H, Morf B, Buschle D, Alkan HF, Ochsenbein AM, Alitalo K, Wolfrum C, Detmar M. Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet. Mol Metab 2014;4:93-105.

Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, Simons M, Djonov V, Knuuti J, Mervaala E, Alitalo K. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol Med 2014;6:307-21.

Marbacher S, Frösén J, Marjamaa J, Anisimov A, Honkanen P, von Gunten M, Abo-Ramadan U, Hernesniemi J, Niemelä M. Intraluminal cell transplantation prevents growth and rupture in a model of rupture-prone saccular aneurysms. Stroke 2014;45:3684-90.

Ollikainen E, Tulamo R, Frösen J, Lehti S, Honkanen P, Hernesniemi J, Niemelä M, Kovanen PT. Mast cells, neovascularization, and microhemorrhages are associated with saccular intracranial artery aneurysm wall remodeling. J Neuropathol Exp Neurol 2014;73:855-64.

Saksi J, Ijäs P, Mäyränpää MI, Nuotio K, Isoviita PM, Tuimala J, Lehtonen-Smeds E, Kaste M, Jula A, Sinisalo J, Nieminen MS, Lokki ML, Perola M, Havulinna AS, Salomaa V, Kettunen J, Jauhiainen M, Kovanen PT, Lindsberg PJ. Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability. Circ Cardiovasc Genet 2014;7:588-98.

Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G. The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev 2014;28:2175-87.

Syrjälä SO, Tuuminen R, Nykänen AI, Raissadati A, Dashkevich A, Keränen MA, Arnaudova R, Krebs R, Leow CC, Saharinen P, Alitalo K, Lemström KB. Angiopoietin-2 inhibition prevents transplant ischemia-reperfusion injury and chronic rejection in rat cardiac allografts. Am J Transplant 2014;14:1096-108.

Syväranta S, Alanne-Kinnunen M, Öörni K, Oksjoki R, Kupari M, Kovanen PT, Helske-Suihko S. Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis. Atherosclerosis 2014;235:398-407.

Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Tonstad S, Wiegman A, Drogari E. Statins for children with familial hypercholesterolemia. Cochrane Database Syst Rev 2014;7: doi: 10.1002/14651858.

Vuorio A, Tikkanen MJ, Kovanen PT. Inhibition of hepatic microsomal triglyceride transfer protein – a novel therapeutic option for treatment of homozygous familial hypercholesterolemia. Vasc Health Risk Manag 2014;10:263-270.

Vuorio T, Nurmi H, Moulton K, Kurkipuro J, Robciuc MR, Ohman M, Heinonen SE, Samaranayake H, Heikura T, Alitalo K, Ylä-Herttuala S. Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis. Arterioscler Thromb Vasc Biol 2014;34:1162-170.

Wang J, Sjöberg S, Tang TT, Öörni K, Wu W, Liu C, Secco B, Tia V, Sukhova GK, Fernandes C, Lesner A, Kovanen PT, Libby P, Cheng X, Shi GP. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biochim Biophys Acta 2014;1842:2174-83.

Wiener Z, Band AM, Kallio P, Högström J, Hyvönen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β. Proc Natl Acad Sci U S A 2014;111:E2229-2236.

Wiener Z, Högström J, Hyvönen V, Band AM, Kallio P, Holopainen T, Dufva O, Haglund C, Kruuna O, Oliver G, Ben-Neriah Y, Alitalo K. Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance. Cell Rep 2014;8:1943-56.

Yao LC, Testini C, Tvorogov D, Anisimov A, Vargas SO, Baluk P, Pytowski B, Claesson-Welsh L, Alitalo K, McDonald DM. Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circ Res 2014;114:806-22.

Zheng W, Aspelund A, Alitalo K. Lymphangiogenic factors, mechanisms, and applications. J Clin Invest 2014;124:878-87.

Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D’Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG, Alitalo K. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes Dev 2014;28:1592-1603.

PhD Thesis

Georgia Zarkada, PhD: VEGFR3 and Notch signaling in angiogenesis, University of Helsinki 2014.

Year 2013

Anisimov A, Leppänen VM, Tvorogov D, Zarkada G, Jeltsch M, Holopainen T, Kaijalainen S, Alitalo K. The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Sci Signal 2013;6:ra52.

Anisimov A, Tvorogov D, Alitalo A, Leppänen VM, An Y, Han EC, Orsenigo F, Gaál EI, Holopainen T, Koh YJ, Tammela T, Korpisalo P, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Dejana E, Koh GY, Choi C, Saharinen P, Alitalo K. Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation 2013;127:424-34.

Badeau RM, Metso J, Kovanen PT, Lee-Rueckert M, Tikkanen MT, Jauhiainen M. The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport. Eur J Clin Invest 2013;43:317-23.

Cilpa-Karhu G, Lipponen K, Samuelsson J, Öörni K, Fornstedt T, Riekkola ML. Three complementary techniques for the clarification of temperature effect on low-density lipoprotein-chondroitin-6-sulfate interaction. Anal Biochem 2013;443:139-47.

Dichlberger A, Kovanen PT, Schneider WJ. Mast cells: from lipid droplets to lipid mediators. Cli Sci (Lond) 2013;125:121-30.

Gaál EI, Tammela T, Anisimov A, Marbacher S, Honkanen P, Zarkada G, Leppänen VM, Tatlisumak T, Hernesniemi J, Niemelä M, Alitalo K. Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization. Blood 2013;122:658-65.

Eklund L, Bry M, Alitalo K. Mouse models for studying angiogenesis and lymphangiogenesis in cancer. Mol Oncol 2013;7:259-82.

Eklund L, Saharinen P. Angiopoietin signaling in the vasculature. Exp Cell Res. 2013;319:1271-80.

Escolà-Gil JC, Julve J, Llaverias G, Urpi-Sarda M, Silvennoinen R, Lee-Rueckert M, Andres-Lacueva C, Blanco-Vaca F. Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo. Transl Res 2013;161:110-7.

Hamm A, Veschini L, Takeda Y, Costa S, Delamarre E, Squadrito ML, Henze AT, Wenes M, Serneels J, Pucci F, Roncal C, Anisimov A, Alitalo K, De Palma M, Mazzone M. PHD2 regulates arteriogenic macrophages through TIE2 signalling. EMBO Mol Med 2013;5:843-57.

Hyvärinen K, Tuomainen AM, Laitinen S, Alfthan G, Salminen I, Leinonen M, Saikku P, Kovanen PT, Jauhiainen M, Pussinen PJ. The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice. BMC Genomics 2013;14:709. doi: 10.1186/1471-2164-14-709.

Ijäs P, Saksi J, Soinne L, Tuimala J, Jauhiainen M, Jula A, Kähönen M, Kesäniemi YA, Kovanen PT, Kaste M, Lindsberg PJ. Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events. Atherosclerosis 2013;230:228-34.

Jeltsch M, Leppänen VM, Saharinen P, Alitalo K. Receptor tyrosine kinase-mediated angiogenesis. Cold Spring Harb Perspect Biol 2013;5. pii: a009183. doi: 10.1101/cshperspect.a009183.

Kallio KA, Hyvärinen K, Kovanen PT, Jauhiainen M, Pussinen PJ. Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function. Metabolism 2013;62:661-8.

Kwon HB, Fukuhara S, Asakawa K, Ando K, Kashiwada T, Kawakami K, Hibi M, Kwon YG, Kim KW, Alitalo K, Mochizuki N. The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish. Development 2013;140:4081-90.

Lappalainen J, Rintahaka J, Kovanen PT, Matikainen S, Eklund K. Intracellular RNA recognition pathway activates strong anti-viral response in human mast cells. Clin Exp Immunol 2013;172:121-8.

Lee-Rueckert M, Blanco-Vaca F, Kovanen PT, Escola-Gil JC. The role of the gut in reverse cholesterol transport – Focus on the enterocyte. Prog Lipid Res 2013;52:317-28.

Lehti S, Käkelä R, Hörkkö S, Kummu O, Helske-Suihko S, Kupari M, Werkkala K, Kovanen PT, Öörni K. Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valves. PLoS One 2013;8:e65810. doi: 10.1371

Leppänen VM, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, Markovic-Mueller S, Stuttfeld E, Goldie KN, Ballmer-Hofer K, Alitalo K. Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proc Natl Acad Sci U S A 2013;110:12960-5.

Maaninka K, Lappalainen J, Kovanen PT. Human mast cells arise from a common circulating progenitor. J Allergy Clin Immunol 2013;132:463-9.

Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, Wiklund O, Hegele RA, Raal FJ, Defesche JC, Wiegman A, Santos RD, Watts GF, Parhofer KG, Kees Hovingh G, Kovanen PT, Boileau C, Averna M, Borén J, Bruckert E, Catapano AL, Kuivenhoven JA, Pajukanta P, Ray K, Stalenhoef AF, Stroes E, Taskinen MR, Tybjærg-Hansen A; for the European Atherosclerosis Society Consensus Panel. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society. Eur Heart J 2013;34:3478-90.

Nurmi K, Virkanen J, Rajamäki K, Niemi K, Kovanen PT, Eklund KK. Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages – a novel anti-inflammatory action of alcohol. PLoS One 2013;8:e78537 doi: 10.1371.

Oksaharju A, Kooistra T, Kleemann R, van Duyvenvoorde W, Miettinen M, Lindstedt KA, Kovanen PT, Korpela R, Kekkonen RA. Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet. Brit J Nutr 2013;110:77-85.

Raissadati A, Jokinen JJ, Syrjälä SO, Keränen MA, Krebs R, Tuuminen R, Arnaudova R, Rouvinen E, Anisimov A, Soronen J, Pajusola K, Alitalo K, Nykänen AI, Lemström K. Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants. Transpl Int 2013;26:1126-37.

Raitakari OT, Mäkinen VP, McQueen MJ, Niemi J, Juonala M, Jauhiainen M, Salomaa V, Hannuksela ML, Savolainen MJ, Kesäniemi AY, Kovanen PT, Sundvall J, Solakivi T, Loo BM, Marniemi J, Hernesniemi J, Lehtimäki T, Kähönen M, Peltonen M, Leiviskä J, Jula A, Anand SS, Miller R, Yusuf S, Viikari JSA, Ala-Korpela M. Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk. Atherosclerosis 2013;226:245-51.

Rajamäki K, Nordström T, Nurmi K, Åkerman KE, Kovanen PT, Öörni K, Eklund KK. Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome. J Biol Chem 2013;288:13410-9.

Robciuc MR, Maranghi M, Lahikainen A, Rader D, Bensadoun A, Öörni K, Metso J, Minicocci I, Ciociola E, Ceci F, Montali A, Arca M, Ehnholm C, Jauhiainen M. Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids. Arterioscler Thromb Vasc Biol 2013;33:1706-13.

Thomas JL, Baker K, Han J, Calvo C, Nurmi H, Eichmann AC, Alitalo K. Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells. Cell Mol Life Sci 2013;70:1779-92.

Vuorio A, Doherty KF, Humphries SE, Kuoppala J, Kovanen PT. Statin treatment of children with familial hypercholesterolemia – Trying to balance incomplete evidence of long-term safety and clinical accountability: Are we approaching a consensus? Atherosclerosis 2013;226:315-20.

Willems S, Vink A, Bot I, Quax PH, de Borst GJ, de Vries JP, van de Weg SM, Moll FL, Kuiper J, Kovanen PT, de Kleijn DP, Hoefer IE, Pasterkamp G. Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events. Eur Heart J 2013;34:3699-706.

PhD Thesis

Suvi Syväranta, MD, PhD: Mechanisms of angiogenesis and lymphangiogenesis in calcific aortic valve stenosis, University of Helsinki 2013.

Wei Zheng, PhD: Regulation of angiogenesis and lymphangiogenesis by endothelial cell signaling molecules, University of Helsinki 2013.

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Wihuri Research Institute

Biomedicum Helsinki
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